Spatial Relation Between Microbleeds and Amyloid Deposits in Amyloid Angiopathy

被引：181

作者：

Dierksen, Gregory A. ^{[1
]}

Skehan, Maureen E. ^{[1
]}

Khan, Muhammad A. ^{[1
]}

Jeng, Jed ^{[1
]}

Nandigam, R. N. Kaveer ^{[1
]}

Becker, John A. ^{[2
]}

Kumar, Ashok ^{[1
]}

Neal, Krista L.

Betensky, Rebecca A. ^{[3
]}

Frosch, Matthew P. ^{[4
]}

Rosand, Jonathan ^{[1
]}

Johnson, Keith A. ^{[2
]}

Viswanathan, Anand ^{[1
]}

Salat, David H. ^{[2
]}

Greenberg, Steven M. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Hemorrhag Stroke Res Program,Dept Neurol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Radiol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[3] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, CS Kubik Lab Neuropathol, Boston, MA USA

来源：

ANNALS OF NEUROLOGY | 2010年 / 68卷 / 04期

基金：

美国国家卫生研究院;

关键词：

PITTSBURGH COMPOUND-B; CEREBRAL MICROBLEEDS; ALZHEIMERS-DISEASE; BRAIN; BETA; IMMUNOTHERAPY; DEMENTIA;

D O I：

10.1002/ana.22099

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Advanced cerebrovascular beta-amyloid deposition (cerebral amyloid angiopathy, CAA) is associated with cerebral microbleeds, but the precise relationship between CAA burden and microbleeds is undefined. We used T2(star)-weighted magnetic resonance imaging (MRI) and noninvasive amyloid imaging with Pittsburgh Compound B (PiB) to analyze the spatial relationship between CAA and microbleeds. On coregistered positron emission tomography (PET) and MRI images, PiB retention was increased at microbleed sites compared to simulated control lesions (p = 0.002) and declined with increasing distance from the microbleed (p < 0.0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition. ANN NEUROL 2010;68:545-548

引用

页码：545 / 548

页数：4

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