Integrated optical pH sensor using replicated chirped grating coupler sensor chips

被引:39
作者
Dubendorfer, J
Kunz, RE
Jobst, G
Moser, I
Urban, G
机构
[1] Ctr Suisse Elect & Microtech SA, CH-8048 Zurich, Switzerland
[2] Paul Scherrer Inst, CH-8048 Zurich, Switzerland
[3] Univ Freiburg, D-79085 Freiburg, Germany
关键词
pH measurement; hydrogel; integrated-optical sensors; photopatterning; chirped-grating coupler; replicated integrated-optical sensors;
D O I
10.1016/S0925-4005(98)00238-X
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Integrated optical sensor chips suitable for high-resolution pH measurements are presented. The pi-I-sensitive swelling of a polymer membrane is detected by refractometry using a compact multi-channel sensor module. The signal transduction is achieved by means of chirped grating couplers which allow simple yet high functionality sensor modules to be built. The experiments have been performed with high sensitivity replicated polycarbonate TiO2 waveguide sensor chips coated with an ultrathin photopatterned hydrogel membrane having functional groups which reversibly change from the neutral state to a charged state upon acidification. A resolution delta pH < + 1.1 x 10(-4) in terms of the pH (at pH 7.5) has been obtained in a dual-channel module with size 10 x 10 x 10 cm(3). (C) 1998 Elsevier Science S.A. All rights reserved.
引用
收藏
页码:210 / 219
页数:10
相关论文
共 33 条
  • [1] OPTIMIZATION OF MULTILAYER INTEGRATED-OPTICS WAVE-GUIDES
    ANEMOGIANNIS, E
    GLYTSIS, EN
    GAYLORD, TK
    [J]. JOURNAL OF LIGHTWAVE TECHNOLOGY, 1994, 12 (03) : 512 - 518
  • [3] *BIOS 1, GRAT COUPL SENS INST
  • [4] Born M., 1980, PRINCIPLES OPTICS, P705
  • [5] MICROMACHINED MULTICHANNEL SYSTEMS FOR THE MEASUREMENT OF CELLULAR-METABOLISM
    BOUSSE, L
    MCREYNOLDS, RJ
    KIRK, G
    DAWES, T
    LAM, P
    BEMISS, WR
    FARCE, JW
    [J]. SENSORS AND ACTUATORS B-CHEMICAL, 1994, 20 (2-3) : 145 - 150
  • [6] Direct observation of affinity reactions by reflected-mode operation of integrated optical grating coupler
    Brandenburg, A
    Polzius, R
    Bier, F
    Bilitewski, U
    Wagner, E
    [J]. SENSORS AND ACTUATORS B-CHEMICAL, 1996, 30 (01) : 55 - 59
  • [7] Camera-Roda G., 1986, Transport Theory and Statistical Physics, V15, P1023, DOI 10.1080/00411458608212729
  • [8] MASS-TRANSPORT WITH RELAXATION IN POLYMERS
    CAMERARODA, G
    SARTI, GC
    [J]. AICHE JOURNAL, 1990, 36 (06) : 851 - 860
  • [9] Permselectivity sensitivity, and amperometric pH sensing at thioctic acid monolayer microelectrodes
    Cheng, Q
    BrajterToth, A
    [J]. ANALYTICAL CHEMISTRY, 1996, 68 (23) : 4180 - 4185
  • [10] Modeling phase transitions and sorption desorption kinetics in thermo-sensitive gels for controlled drug delivery systems
    Colombo, I
    Grassi, M
    Fermeglia, M
    Lapasin, R
    Pricl, S
    [J]. FLUID PHASE EQUILIBRIA, 1996, 116 (1-2) : 148 - 161