Human natural killer cell activating receptors

被引:28
作者
Biassoni, R
Cantoni, C
Falco, M
Pende, D
Millo, R
Moretta, L
Bottino, C
Moretta, A
机构
[1] CBA, IST, Immunol Lab, Ist Nazl Ric Canc, I-16132 Genoa, Italy
[2] Univ Studi Genova, Dipartimento Med Sperimentale, Genoa, Italy
[3] Ist Giannina Gaslini, I-16148 Genoa, Italy
关键词
receptors; natural killer; HLA;
D O I
10.1016/S0161-5890(01)00018-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Natural killer (NK) cells were poorly characterized until 10 years ago and few molecules expressed on their cell surface were known. Now the situation has changed dramatically, since a plethora of receptors characterized by opposite functions have been functionally and molecularly defined. NK cells express clonally distributed inhibitory receptors specific for different groups of HLA class I alleles, thus protecting normal cells from NK-mediated lysis. On the contrary various activating receptors are involved in triggering of NK-mediated natural cytotoxicity, Their engagement induces human NK cells to kill target cells that are either HLA class I-negative or -deficient. Here a brief description of the activating receptors and coreceptor and of their ligand(s) is given. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1015 / 1024
页数:10
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