Vasorelaxant effects of the bioflavonoid chrysin in isolated rat aorta

被引：47

作者：

Duarte, J ^{[1
]}

Jiménez, R

Villar, IC

Pérez-Vizcaíno, F

Jiménez, J

Tamargo, J

机构：

[1] Univ Granada, Sch Pharm, Dept Pharmacol, E-18071 Granada, Spain

[2] Univ Complutense Madrid, Sch Med, Dept Pharmacol, Madrid, Spain

来源：

PLANTA MEDICA | 2001年 / 67卷 / 06期

关键词：

D O I：

10.1055/s-2001-16492

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chrysin relaxed the contractions induced by noradrenaline in isolated endothelium-intact rat aortic rings (IC50 = 16 +/- 4 muM). Endothelium removal and Nc-nitro-L-arginine methyl ester inhibited this relaxant effect. Chrysin potentiated the relaxation to acetylcholine under control conditions or after incubation with the superoxide anion generator hypoxanthine/xanthine oxidase. It also potentiated the relaxation induced by 3-morpholino-sydnonimine, sodium nitroprusside, and 8-bromoguanosine-3 ' :5 '- cyclic-monophosphate. Therefore, vasorelaxation induced by chrysin in the rat aorta is endothelium- and NO-dependent. This effect is mediated by the prevention of O-2(-)-induced inactivation of endothelial derived NO and also by the potentiation of cGMP-induced vasodilatation.

引用

页码：567 / 569

页数：3

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