The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells

被引：151

作者：

Oberlies, NH ^{[1
]}

Croy, VL ^{[1
]}

Harrison, ML ^{[1
]}

McLaughlin, JL ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & MOL PHARMACOL,W LAFAYETTE,IN 47907

来源：

CANCER LETTERS | 1997年 / 115卷 / 01期

关键词：

acetogenins; bullatacin; multidrug resistance; P-gp; mammary adenocarcinoma;

D O I：

10.1016/S0304-3835(97)04716-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：73 / 79

页数：7

共 28 条

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