tRNA's modifications bring order to gene expression

被引：187

作者：

Gustilo, Estella M. ^{[1
]}

Vendeix, Franck A. P. ^{[1
]}

Agris, Paul F. ^{[1
]}

机构：

[1] N Carolina State Univ, Raleigh, NC 27695 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2008年 / 11卷 / 02期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.mib.2008.02.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The posttranscriptional modification of RNA is a significant investment in genes, enzymes, substrates, and energy. Advances in molecular genetics and structural biology indicate strongly that modifications of tRNA's anticoclon domain control gene expression. Modifications at the anticodon's wobble position are required for recognition of rarely used codons and restrict or expand codon recognition depending on their chemistries. A shift of the translational reading frame occurs in the absence of modifications at either wobble position-34 or the conserved purine-37, 3'-adjacent to the anticodon, causing expression of alternate protein sequences. These modifications have in common their contribution of order to tRNA's anticodon.

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收藏

页码：134 / 140

页数：7

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