Mechanisms for decreased function of B cells in aged mice and humans

被引：69

作者：

Frasca, Daniela ^{[1
,2
]}

Landin, Ana Marie ^{[1
]}

Riley, Richard L. ^{[1
]}

Blomberg, Bonnie B. ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami, FL 33101 USA

[2] Univ Roma La Sapienza, Grad Sch Cell Biol & Dev, Rome, Italy

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 180卷 / 05期

关键词：

D O I：

10.4049/jimmunol.180.5.2741

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune system has been known for some time to be compromised in aged individuals, e.g., both mice and humans, and in both humoral and cellular responses. Our studies have begun to elucidate intrinsic B lymphocyte defects in Ig class switch recombination, activation-induced cytidine deaminase, and E47 transcription factor expression. These defects occur in both mice and humans. Our studies have also shown that tristetraprolin is one of the key players in regulating the decreased E47 mRNA stability in aged B lymphocytes. These and current studies should lead to improvements in B lymphocyte function in aged populations.

引用

页码：2741 / 2746

页数：6

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