Renal tubular dysgenesis associated with in utero exposure to Nimuselide

被引：7

作者：

Ali, US

Khubchandani, S

Andankar, P

Parekhji, S

Dubhalish, V

Padhye, B

机构：

[1] BJ Wadia Hosp Children & Res Ctr, Div Nephrol, Bombay, Maharashtra, India

[2] Jaslok Hosp & Res Ctr, Dept Pathol, Bombay, Maharashtra, India

来源：

PEDIATRIC NEPHROLOGY | 2006年 / 21卷 / 02期

关键词：

nimuselide; renal tubular dysgenesis; neonatal renal failure; COX-2; inhibitors; drug ingestion in pregnancy;

D O I：

10.1007/s00467-005-2089-0

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Maternal ingestion of the selective cyclo-oxygenase-2 (COX-2) inhibitor Nimuselide has been reported to be associated with the development of oligohydramnios and neonatal renal failure in some cases. We report a case of neonatal renal failure associated with maternal ingestion of Nimuselide in the third trimester of pregnancy. The neonate presented with metabolic acidosis and non-oliguric renal failure on the second day of life. The renal histopathology showed evidence of renal tubular dysgenesis. The child continues to have elevated serum creatinine and hypertension at 10 months of age.

引用

收藏

页码：274 / 276

页数：3

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