Techniques for analysis and purification in high-throughput chemistry

被引：28

作者：

Hughes, I ^{[1
]}

Hunter, D ^{[1
]}

机构：

[1] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(00)00198-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The success of combinatorial chemistry, and the increased emphasis on single well-characterised compounds of high purity, has had a significant impact on analytical and purification technologies. The requirement for ever-increasing throughput has led to the automation and parallelisation of these techniques. Advances have also been made in developing faster methods to augment throughput further.

引用

页码：243 / 247

页数：5

共 63 条

[1] The development of a semi-preparatory scale supercritical-fluid chromatograph for high-throughput purification of 'combi-chem' libraries
Berger, TA
Fogleman, K
Staats, T
Bente, P
Crocket, I
Farrell, W
Osonubi, M
[J]. JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 2000, 43 (1-3): : 87 - 111
[2] High-speed screening of combinatorial libraries by gradient packed-column supercritical fluid chromatography
Berger, TA
Wilson, WH
[J]. JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 2000, 43 (1-3): : 77 - 85
[3] Solid-supported reagent strategies for rapid purification of combinatorial synthesis products
Booth, RJ
Hodges, JC
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (01) : 18 - 26
[4] Coffey P, 1999, AM LAB, V31, P57
[5] High-throughput preparative separations from combinatorial libraries
Coleman, K
[J]. ANALUSIS, 1999, 27 (08) : 719 - 723
[6] Curran DP, 1998, ANGEW CHEM INT EDIT, V37, P1175, DOI 10.1002/(SICI)1521-3773(19980518)37:9<1174::AID-ANIE1174>3.0.CO
[7] 2-P
[8] de Biasi V, 1999, RAPID COMMUN MASS SP, V13, P1165, DOI 10.1002/(SICI)1097-0231(19990630)13:12<1165::AID-RCM638>3.0.CO
[9] 2-4
[10] Analyses of compound libraries obtained by high-throughput parallel synthesis:: strategy of quality control by high-performance liquid chromatography, mass spectrometry and nuclear magnetic resonance techniques
Duléry, BD
Verne-Mismer, J
Wolf, E
Kugel, C
Van Hijfte, L
[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1999, 725 (01): : 39 - 47

← 1 2 3 4 5 6 7 →