beta-1,2-linked oligomannosides inhibit Candida albicans binding to murine macrophage

被引:70
作者
Fradin, C
Jouault, T
Mallet, A
Mallet, JM
Camus, D
Sinay, P
Poulain, D
机构
[1] INSERM U42,F-59650 VILLENEUVE DASCQ,FRANCE
[2] ECOLE NORMALE SUPER,DEPT CHIM,URA CNRS 1686,F-75231 PARIS,FRANCE
[3] CHU LILLE,FAC MED,SERV PARASITOL MYCOL,F-59037 LILLE,FRANCE
关键词
yeast; interaction; receptors;
D O I
10.1002/jlb.60.1.81
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Interaction of Candida albicans with cells of the macrophage lineage was examined by using heat-killed (HK) and live yeast cells. Laminarin, an analogue of the cell wall beta-glucans, strongly inhibited HK yeasts adherence to J774 cell line but had no effect on Live yeast binding. Phosphopeptidolmannan (PPM) from Saccharomyces cerevisiae had a limited effect on the binding of both HK and live yeasts but significant inhibition was achieved by the use of C., albicans PPM. The role of beta-1,2-oligomannosides was examined with regard to their exclusive presence within C, albicans PPM, PPM acid labile beta-1,2-oligomannosides or a synthetic beta-1,2-mannotetraose, inhibited yeasts binding in a maimer comparable to the original PPM, These latter results were confirmed by using mouse peritoneal macrophages, thus suggesting a general role for beta-1,2-olgomannosides in the adherence of the yeast to the macrophage membrane.
引用
收藏
页码:81 / 87
页数:7
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