Engineering metabolic highways in Lactococci and other lactic acid bacteria

被引：102

作者：

de Vos, WM

Hugenholtz, J

机构：

[1] Wageningen Ctr Food Sci, NL-6700 AN Wageningen, Netherlands

[2] Wageningen Univ, Microbiol Lab, NL-6703 CT Wageningen, Netherlands

[3] NIZO Food Res, Dept Flavour Ingredients & Nutr, NL-6700 BA Ede, Netherlands

来源：

TRENDS IN BIOTECHNOLOGY | 2004年 / 22卷 / 02期

关键词：

D O I：

10.1016/j.tibtech.2003.11.011

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lactic acid bacteria (LAB) are widely used in industrial food fermentations and are receiving increased attention for use as cell factories for the production of food and pharmaceutical products. Glycolytic conversion of sugars into lactic acid is the main metabolic highway in these Gram-positive bacteria and Lactococcus lactis has become the model organism because of its small genome, genetic accessibility and simple metabolism. Here we discuss the metabolic engineering of L. lactis and the value of metabolic models compared with other LAB, with a particular focus on the food-grade production of metabolites involved in flavour, texture and health.

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页码：72 / 79

页数：8

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