Polyelectrolytes for cell encapsulation

被引:114
作者
Bhatia, SR [1 ]
Khattak, SF [1 ]
Roberts, SC [1 ]
机构
[1] Univ Massachusetts, Dept Chem Engn, Goessmann Lab 159, Amherst, MA 01003 USA
关键词
alginate; tissue engineering; polyelectrolyte complexes; polyelectrolyte gels; immunoprotective membranes;
D O I
10.1016/j.cocis.2005.05.004
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Recent advances in the use of polyelectrolyte materials for cell encapsulation are reviewed, with a focus on three current challenges: tunable mechanical properties, controlled cell adhesion, and enhanced oxygen supply. New notable results include methods for creating stable alginate-silica complexes, techniques for incorporating RGD-containing peptides into alginate gels, and an improved understanding of the effect of charge density on cell-material interactions. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:45 / 51
页数:7
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