Adaptive immunity affects learning behavior in mice

被引：164

作者：

Brynskikh, Anna ^{[1
]}

Warren, Ted ^{[1
]}

Zhu, Julia ^{[1
]}

Kipnis, Jonathan ^{[1
]}

机构：

[1] Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Lab NeuroImmune Regulat, Omaha, NE 68198 USA

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2008年 / 22卷 / 06期

关键词：

cells; cognition; radial arm water maze; Morris water maze; Barnes maze; open field; bone marrow transplantation;

D O I：

10.1016/j.bbi.2007.12.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulation of neuronal plasticity by the immune system is an evolving field of modern neuroscience. Here we employ immune deficient mice to examine the role of the immune system in learning behavior of mice in a variety of cognitive tasks. While no motivation or motor function deficits are evident in severe combined immune deficient (scid) mice, there was significant impairment in acquisition of cognitive tasks as compared to wild-type (WT) control mice. Moreover, acute depletion of adaptive immunity in adult WT mice significantly impaired learning behavior. Passive transfer of autologous T cells into WT mice following ablation of adaptive immunity restored previously impaired cognitive function. These results suggest that throughout lifetime, immune system supports cognitive function and may therefore have far-reaching therapeutic implications for cognitive disorders. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：861 / 869

页数：9

共 32 条

[1] LETHALLY IRRADIATED NORMAL STRAINS OF MICE RADIOPROTECTED WITH SCID BONE-MARROW DEVELOP SENSITIVITY TO LOW-DOSES OF STAPHYLOCOCCAL-ENTEROTOXIN-E [J].