Investigation of glycerol incorporation into soraphen A

被引：25

作者：

Hill, AM ^{[1
]}

Harris, JP ^{[1
]}

Siskos, AP ^{[1
]}

机构：

[1] Univ London Kings Coll, Dept Chem, London WC2R 2LS, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 21期

关键词：

D O I：

10.1039/a806112b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Glycerol has been incorporated mid-chain into the polyketide soraphen A 1 at C-3,4 and C-11,12; the pro-(S)-hydroxymethyl group of glycerol is lost and one of the hydrogens in the pro-(R)-hydroxymethyl group is retained at C-11 which excludes hydroxymalonate as the immediate precursor to the vicinal methoxy groups at C-11,12.

引用

页码：2361 / 2362

页数：2

共 12 条

[1] BEDORF N, UNPUB
[2] METABOLIC PRODUCTS OF MICROORGANISMS .265. PRELACTONE-C AND PRELACTONE-B, OLIGOKETIDES FROM STREPTOMYCES PRODUCING CONCANAMYCINS AND BAFILOMYCINS
BINDSEIL, KU
ZEECK, A
[J]. HELVETICA CHIMICA ACTA, 1993, 76 (01) : 150 - 157
[3] BIOSYNTHETIC ORIGIN OF C2 UNITS OF GELDANAMYCIN AND DISTRIBUTION OF LABEL FROM D-[6-13C]GLUCOSE
HABER, A
JOHNSON, RD
RINEHART, KL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (10) : 3541 - 3544
[4] HILL AF, UNPUB
[5] HILL RE, 1987, J BIOL CHEM, V262, P7463
[6] TRANSFER OF MOBILIZABLE PLASMIDS TO SORANGIUM-CELLOSUM AND EVIDENCE FOR THEIR INTEGRATION INTO THE CHROMOSOME
JAOUA, S
NEFF, S
SCHUPP, T
[J]. PLASMID, 1992, 28 (02) : 157 - 165
[7] Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis
Kakavas, SJ
Katz, L
Stassi, D
[J]. JOURNAL OF BACTERIOLOGY, 1997, 179 (23) : 7515 - 7522
[8] Biosynthesis of fluoroacetate and 4-fluorothreonine by Streptomyces cattleya. The stereochemical processing of glycerol
Nieschalk, J
Hamilton, JTG
Murphy, CD
Harper, DB
OHagan, D
[J]. CHEMICAL COMMUNICATIONS, 1997, (08) : 799 - 800
[9] O'Hagan D., 1991, The Polyketide Metabolites
[10] Biosynthesis of macrophomic acid: Plausible involvement of intermolecular Diels-Alder reaction
Oikawa, H
Yagi, K
Watanabe, K
Honma, M
Ichihara, A
[J]. CHEMICAL COMMUNICATIONS, 1997, (01) : 97 - 98

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