Investigation of glycerol incorporation into soraphen A

被引：25

作者：

Hill, AM ^{[1
]}

Harris, JP ^{[1
]}

Siskos, AP ^{[1
]}

机构：

[1] Univ London Kings Coll, Dept Chem, London WC2R 2LS, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 21期

关键词：

D O I：

10.1039/a806112b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Glycerol has been incorporated mid-chain into the polyketide soraphen A 1 at C-3,4 and C-11,12; the pro-(S)-hydroxymethyl group of glycerol is lost and one of the hydrogens in the pro-(R)-hydroxymethyl group is retained at C-11 which excludes hydroxymalonate as the immediate precursor to the vicinal methoxy groups at C-11,12.

引用

页码：2361 / 2362

页数：2

共 12 条

[11] BIOSYNTHETIC ORIGIN OF CARBON-3 AND CARBON-4 OF LEUCOMYCIN AGLYCONE
OMURA, S
TSUZUKI, K
NAKAGAWA, A
LUKACS, G
[J]. JOURNAL OF ANTIBIOTICS, 1983, 36 (05) : 611 - 613
[12] A SORANGIUM-CELLULOSUM (MYXOBACTERIUM) GENE-CLUSTER FOR THE BIOSYNTHESIS OF THE MACROLIDE ANTIBIOTIC SORAPHEN A - CLONING, CHARACTERIZATION, AND HOMOLOGY TO POLYKETIDE SYNTHASE GENES FROM ACTINOMYCETES
SCHUPP, T
TOUPET, C
CLUZEL, B
NEFF, S
HILL, S
BECK, JJ
LIGON, JM
[J]. JOURNAL OF BACTERIOLOGY, 1995, 177 (13) : 3673 - 3679

← 1 2 →