Isothiazoles. Part 14: New 3-aminosubstituted isothiazole dioxides and their mono- and dihalogeno derivatives

被引：13

作者：

Clerici, F

Contini, A

Gelmi, ML

Pocar, D

机构：

[1] Univ Milan, Lab Chim Organ A Marchesini, Fac Farm, I-20133 Milan, Italy

[2] Univ Milan, Ctr Interuniv Ric Reazioni Pericicliche & Sintesi, I-20133 Milan, Italy

来源：

TETRAHEDRON | 2003年 / 59卷 / 47期

关键词：

isothiazoles halogenoisothiazoles; halogenation; quantum chemical calculations;

D O I：

10.1016/j.tet.2003.09.064

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Alkylamino- and 3-arylamino isothiazole dioxides unsubstituted at C-4 and C-5 were synthesized starting from dithiopropionic amides. Taking advantage of the direct chlorination during the cyclization process or realizing an addition-elimination process with bromine on the final 3-aminoisothiazole dioxide derivatives, the corresponding 5-chloro-, 4,5-dichloro- or the 4-bromoisothiazole dioxides could also be made available. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：9399 / 9408

页数：10

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