The impact of pregnancy and childbirth on the metabolism of lamotrigine

被引：163

作者：

Pennell, PB ^{[1
]}

Newport, DJ

Stowe, ZN

Helmers, SL

Montgomery, JQ

Henry, TR

机构：

[1] Emory Univ, Sch Med, Dept Neurol, WMB 6000, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA

[3] Emory Univ, Sch Med, Dept Gynecol & Obstet, Atlanta, GA 30322 USA

来源：

NEUROLOGY | 2004年 / 62卷 / 02期

关键词：

D O I：

10.1212/01.WNL.0000103286.47129.F8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study was performed to clarify alterations in lamotrigine (LTG) clearance during pregnancy and childbirth. Fourteen women on LTG monotherapy had LTG concentration samples obtained before conception and monthly. LTG apparent clearance, weight-adjusted relative clearance, and percentages of baseline clearance significantly differed between preconception baseline and each trimester and between trimesters. LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline.

引用

页码：292 / 295

页数：4

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