Liposomes and niosomes as topical drug delivery systems

被引:183
作者
Choi, MJ [1 ]
Maibach, HI [1 ]
机构
[1] Univ Calif San Francisco, Sch Med, Dept Dermatol, San Francisco, CA 94143 USA
关键词
proliposomes; topical/transdermal delivery; follicular transport; liposomes; niosomes; proniosomes;
D O I
10.1159/000086666
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The skin acts as a major target as well as a principle barrier for topical/transdermal (TT) drug delivery. The stratum corneum plays a crucial role in barrier function for TT drug delivery. Despite major research and development efforts in TT systems and the advantages of these routes, low stratum corneum permeability limits the usefulness of topical drug delivery. To overcome this, methods have been assessed to increase permeation. One controversial method is the use of vesicular systems, such as liposomes and niosomes, whose effectiveness depends on their physicochemical properties. This review focuses on the effect of liposomes and niosomes on enhancing drug penetration, and defines the effect of composition, size and type of the vesicular system on TT delivery Copyright (C) 2005 S. Karger AG, Basel.
引用
收藏
页码:209 / 219
页数:11
相关论文
共 73 条
[1]   INTERACTION BETWEEN CORNEOCYTES AND STRATUM-CORNEUM LIPID LIPOSOMES INVITRO [J].
ABRAHAM, W ;
DOWNING, DT .
BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1021 (02) :119-125
[2]   Preparation and in vitro evaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol [J].
Agarwal, R ;
Katare, OP ;
Vyas, SP .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 228 (1-2) :43-52
[3]   ESTIMATION OF THE PORE-SIZE AND CHARGE-DENSITY IN HUMAN CADAVER SKIN [J].
AGUILELLA, V ;
KONTTURI, K ;
MURTOMAKI, L ;
RAMIREZ, P .
JOURNAL OF CONTROLLED RELEASE, 1994, 32 (03) :249-257
[4]   PROLIPOSOMES AS AN INTRANASAL DOSAGE FORM FOR THE SUSTAINED DELIVERY OF PROPRANOLOL [J].
AHN, BN ;
KIM, SK ;
SHIM, CK .
JOURNAL OF CONTROLLED RELEASE, 1995, 34 (03) :203-210
[5]   Iontophoresis and electroporation: comparisons and contrasts [J].
Banga, AK ;
Bose, S ;
Ghosh, TK .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 179 (01) :1-19
[6]   Novel mechanisms and devices to enable successful transdermal drug delivery [J].
Barry, BW .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 14 (02) :101-114
[7]   Physical and physiological effects of stratum corneum tape stripping [J].
Bashir, SJ ;
Chew, AL ;
Anigbogu, A ;
Dreher, F ;
Maibach, HI .
SKIN RESEARCH AND TECHNOLOGY, 2001, 7 (01) :40-48
[8]   Effect of barrier perturbation on cutaneous penetration of salicylic acid in hairless rats: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function [J].
Benfeldt, E ;
Serup, J .
ARCHIVES OF DERMATOLOGICAL RESEARCH, 1999, 291 (09) :517-526
[9]   Heparin penetration into and permeation through human skin from aqueous and liposomal formulations in vitro [J].
Betz, G ;
Nowbakht, P ;
Imboden, R ;
Imanidis, G .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 228 (1-2) :147-159
[10]   Structure of the skin barrier and its modulation by vesicular formulations [J].
Bouwstra, JA ;
Honeywell-Nguyen, PL ;
Gooris, GS ;
Ponec, M .
PROGRESS IN LIPID RESEARCH, 2003, 42 (01) :1-36