HIV Nef:: Role in pathogenesis and viral fitness

被引：41

作者：

Arien, Kevin K. ^{[1
]}

Verhasselt, Bruno ^{[1
]}

机构：

[1] Univ Ghent, Fac Med & Hlth Sci, Dept Clin Chem Microbiol & Immunol, HIVLab, B-9000 Ghent, Belgium

来源：

CURRENT HIV RESEARCH | 2008年 / 6卷 / 03期

关键词：

HIV; Nef; fitness; pathogenesis; replication;

D O I：

10.2174/157016208784325001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.

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页码：200 / 208

页数：9

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