Serotonin (5-HT)2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely-moving rats

被引:152
作者
Gobert, A [1 ]
Millan, MJ [1 ]
机构
[1] Inst Rech Servier, Dept Psychopharmacol, F-78290 Paris, France
关键词
frontal cortex; 5-HT2C receptors; dopamine; noradrenaline;
D O I
10.1016/S0028-3908(98)00188-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The 5HT(2) receptor agonist, DOI, dose-dependently (0.16-10.0 mg/kg, s.c.) increased dialysate levels of dopamine (DA) and noradrenaline (NA), but not 5-HT, in the frontal cortex (FCX) of freely-moving rats. This action was abolished by the selective 5-HT2A antagonist, MDL100,907 (0.04), which did not, itself, modify levels of DA and NA. In contrast, the selective 5-HT2B/2C antagonist, SB206,553 (0.63), increased levels of DA and NA additively with DOI. Thus, in contrast to a tonic, inhibitory influence of 5-HT2C receptors (see Millan, M.J., Dekeyne, A., Gobert, A., 1998. Serotonin (5-HT)(2C) receptors tonically inhibit dopamine (DA) and noradrenaline (NAD), but not 5-HT, release in the FCX in vivo. Neuropharmacology 37, 953-955), 5-HT2A receptors exert a phasic, facilitatory influence upon FCX levels of DA and NA. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:315 / 317
页数:3
相关论文
共 10 条
  • [1] A 5-HYDROXYTRYPTAMINE(2) AGONIST AUGMENTS GAMMA-AMINOBUTYRIC-ACID AND EXCITATORY AMINO-ACID INPUTS TO NORADRENERGIC LOCUS-CERULEUS NEURONS
    CHIANG, C
    ASTONJONES, G
    [J]. NEUROSCIENCE, 1993, 54 (02) : 409 - 420
  • [2] BIOCHEMICAL-EVIDENCE FOR THE REGULATION OF CENTRAL NORADRENERGIC ACTIVITY BY 5-HT1A AND 5-HT2 RECEPTORS - MICRODIALYSIS STUDIES IN THE AWAKE AND ANESTHETIZED RAT
    DONE, CJG
    SHARP, T
    [J]. NEUROPHARMACOLOGY, 1994, 33 (3-4) : 411 - 421
  • [3] In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties
    Kennett, GA
    Wood, MD
    Bright, F
    Cilia, J
    Piper, DC
    Gager, T
    Thomas, D
    Baxter, GS
    Forbes, IT
    Ham, P
    Blackburn, TP
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1996, 117 (03) : 427 - 434
  • [4] Dopamine, the prefrontal cortex and schizophrenia
    Knable, MB
    Weinberger, DR
    [J]. JOURNAL OF PSYCHOPHARMACOLOGY, 1997, 11 (02) : 123 - 131
  • [5] MD K., 1996, Modul. Dopaminergic Neurotransmission by Other Neurotransmitters, P87
  • [6] Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo
    Millan, MJ
    Dekeyne, A
    Gobert, A
    [J]. NEUROPHARMACOLOGY, 1998, 37 (07) : 953 - 955
  • [7] PENNINGTON NJ, 1996, PROG NEUROPSYCHOPHAR, V20, P951
  • [8] ACTIONS OF 5-HYDROXYTRYPTAMINE ON VENTRAL TEGMENTAL AREA NEURONS OF THE RAT IN-VITRO
    PESSIA, M
    JIANG, ZG
    NORTH, RA
    JOHNSON, SW
    [J]. BRAIN RESEARCH, 1994, 654 (02) : 324 - 330
  • [9] THE SELECTIVE 5-HT2A RECEPTOR ANTAGONIST, MDL-100,907, INCREASES DOPAMINE EFFLUX IN THE PREFRONTAL CORTEX OF THE RAT
    SCHMIDT, CJ
    FADAYEL, GM
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 273 (03) : 273 - 279
  • [10] SCHREIBER R, 1995, J PHARMACOL EXP THER, V273, P101