Mild copper-catalyzed N-arylation of azaheterocycles with aryl halides

被引：78

作者：

Kuil, M

Bekedam, EK

Visser, GM

van den Hoogenband, A

Terpstra, JW

Kamer, PCJ

van Leeuwen, PWNM

van Strijdonck, GPF

机构：

[1] Solvay Pharmaceut, NL-1380 DA Weesp, Netherlands

[2] Hoff Inst Mol Sci, NL-1018 WV Amsterdam, Netherlands

[3] Univ Wageningen & Res Ctr, Organ Chem Lab, NL-6703 HB Wageningen, Netherlands

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 14期

关键词：

D O I：

10.1016/j.tetlet.2005.02.074

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient copper(I)-catalyzed N-arylation of azaheterocycles with various aryl halides is reported. The N-arylation reaction can be carried out using as low as 0.5 mol% of (Cu(I)OTf)(2)center dot PhH and 1.0 mol% of 4,7-dichloro-1,10-phenanthroline as the ligand. Furthermore, cheap and stable copper precursors like Cu(I)I and Cu(II)(OAc)(2)-H2O and the cheap and mild base K2CO3 can be used. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：2405 / 2409

页数：5

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