Interferon gamma, IL-12, IL-12R and STAT-1 immunodeficiency diseases: disorders of the interface of innate and adaptive immunity

被引：35

作者：

Holland, Steven M. ^{[1
]}

机构：

[1] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA

来源：

IMMUNOLOGIC RESEARCH | 2007年 / 38卷 / 1-3期

关键词：

mycobacteria; salmonella; tuberculosis; dominant; recessive;

D O I：

10.1007/s12026-007-0045-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Susceptibility to mycobacterial infection has long been associated with defects in T cell immunity, such as those conferred by HIV infection or iatrogenic immune suppression. However, despite these well-recognized predispositions to clinical disease with tuberculosis and nontuberculous mycobacteria, the genetic disorders that are relatively specific for mycobacterial infection with nontuberculous bacteria and bacille Calmette Guerin (BCG) involve the innate immune pathways, and all engage interferon Gamma and IL-12 production, signaling, and availability.

引用

页码：342 / 346

页数：5

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