Interferon-γ and interleukin-12 pathway defects and human disease

被引：259

作者：

Dorman, SE ^{[1
]}

Holland, SM ^{[1
]}

机构：

[1] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2000年 / 11卷 / 04期

关键词：

interferon-gamma; interferon-gamma receptor deficiency; interleukin-12; tuberculosis; mycobacteria;

D O I：

10.1016/S1359-6101(00)00010-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A genetic component to human mycobacterial disease susceptibility has long been postulated. Over the past five years, mutations in the interferon-gamma (IFN gamma) receptor, IL-12 receptor beta 1 (IL-12R beta 1), and IL-12 p40 genes have been recognized. These mutations are associated with heightened susceptibility to disease caused by intracellular pathogens including nontuberculous mycobacteria, vaccine-associated bacille Calmette Guerin (BCG), Salmonella species, and some viruses. We describe the genotype-phenotype correlations in IFN gamma receptor, IL-12R beta 1, and IL-12 p40 deficiency, and discuss how study of these diseases has enhanced knowledge of human host defense against mycobacteria and other intracellular pathogens. Published by Elsevier Science Ltd.

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收藏

页码：321 / 333

页数：13

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