Statins inhibit the antirheumatic effects of rituximab in rheumatoid arthritis: results from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry

被引:29
作者
Arts, E. E. A. [1 ]
Jansen, T. L. [2 ]
Den Broeder, A.
Vonkeman, H. E. [3 ,4 ]
Dutmer, E. [5 ]
Van de Laar, M. A. F. J. [3 ,4 ]
Van Riel, P. L. C. M. [1 ]
Fransen, J. [1 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, NL-6500 HB Nijmegen, Netherlands
[2] Med Ctr Leeuwarden, Dept Rheumatol, Leeuwarden, Netherlands
[3] Med Spectrum Twente, Dept Rheumatol, Enschede, Netherlands
[4] Univ Twente, NL-7500 AE Enschede, Netherlands
[5] Gelderse Vallei Hosp, Dept Rheumatol, Ede, Netherlands
关键词
NON-HODGKINS-LYMPHOMA; MONOCLONAL-ANTIBODY THERAPY; B-CELL LYMPHOMA; LIPID RAFTS; APOPTOSIS;
D O I
10.1136/ard.2010.136093
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
引用
收藏
页码:877 / 878
页数:2
相关论文
共 9 条
[1]
Drug therapy: Monoclonal antibody therapy for B-cell non-Hodgkin's lymphoma [J].
Cheson, Bruce D. ;
Leonard, John P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (06) :613-626
[2]
Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy - Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks [J].
Cohen, Stanley B. ;
Emery, Paul ;
Greenwald, Maria W. ;
Dougados, Maxime ;
Furie, Richard A. ;
Genovese, Mark C. ;
Keystone, Edward C. ;
Loveless, James E. ;
Burmester, Gerd-Ruediger ;
Cravets, Matthew W. ;
Hessey, Eva W. ;
Shaw, Timothy ;
Totoritis, Mark C. .
ARTHRITIS AND RHEUMATISM, 2006, 54 (09) :2793-2806
[3]
CD20-mediated apoptosis: signalling through lipid rafts [J].
Deans, JP ;
Li, HD ;
Polyak, MJ .
IMMUNOLOGY, 2002, 107 (02) :176-182
[4]
Goldstein MR, 2009, NEW ENGL J MED, V360, P192, DOI 10.1056/NEJMc081871
[5]
Rituxan (anti-CD20 antibody)-induced translocation of CD20 into lipid rafts is crucial for calcium influx and apoptosis [J].
Janas, E ;
Priest, R ;
Wilde, JI ;
White, JH ;
Malhotra, R .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2005, 139 (03) :439-446
[6]
Statin Use and Prognosis in Patients With Diffuse Large B-Cell Lymphoma and Follicular Lymphoma in the Rituximab Era [J].
Nowakowski, Grzegorz S. ;
Maurer, Matthew J. ;
Habermann, Thomas M. ;
Ansell, Stephen M. ;
Macon, William R. ;
Ristow, Kay M. ;
Allmer, Cristine ;
Slager, Susan L. ;
Witzig, Thomas E. ;
Cerhan, James R. .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (03) :412-417
[7]
Interaction Between Statins and Rituximab in Non-Hodgkin's Lymphoma [J].
Rabinowitz, Ian .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (33) :5486-5486
[8]
Concomitant statin use does not impair the clinical outcome of patients with diffuse large B cell lymphoma treated with rituximab-CHOP [J].
Samaras, Panagiotis ;
Heider, Helen ;
Haile, Sarah R. ;
Petrausch, Ulf ;
Schaefer, Niklaus G. ;
Siciliano, Raffaele Daniele ;
Meisel, Alexander ;
Mischo, Axel ;
Zweifel, Martin ;
Knuth, Alexander ;
Stenner-Liewen, Frank ;
Renner, Christoph .
ANNALS OF HEMATOLOGY, 2010, 89 (08) :783-787
[9]
Statins impair antitumor effects of rituximab by inducing conformational changes of CD20 [J].
Winiarska, Magdalena ;
Bil, Jacek ;
Wilczek, Ewa ;
Wilczynski, Grzegorz M. ;
Lekka, Malgorzata ;
Engelberts, Patrick J. ;
Mackus, Wendy J. M. ;
Gorska, Elzbieta ;
Bojarski, Lukasz ;
Stoklosa, Tomasz ;
Nowis, Dominika ;
Kurzaj, Zuzanna ;
Makowski, Marcin ;
Glodkowska, Eliza ;
Issat, Tadeusz ;
Mrowka, Piotr ;
Lasek, Witold ;
Dabrowska-Iwanicka, Anna ;
Basak, Grzegorz W. ;
Wasik, Maria ;
Warzocha, Krzysztof ;
Sinski, Maciej ;
Gaciong, Zbigniew ;
Jakobisiak, Marek ;
Parren, Paul W. H. I. ;
Golab, Jakub .
PLOS MEDICINE, 2008, 5 (03) :0502-0517