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Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor γ (PPARγ) agonists

被引：28
作者：
Ahn, Jin Hee [1 ]
Shin, Mi Sik
Jung, Sun Ho
Kim, Jin Ah
Kim, Hye Min
Kim, Se Hoan
Kanga, Seung Kyu
Kim, Kwang Rok
Dal Rhee, Sang
Park, Sung Dae
Lee, Jae Mok
Lee, Jeong Hyung
Cheon, Hyae Gyeong
Kim, Sung Soo
机构：
[1] Korea Res Inst Chem Technol, Bioorgan Sci Div, Taejon 305600, South Korea
[2] JEIL Pharmaceut Co Ltd, R&D Ctr, Yongin 449861, South Korea
[3] CJ Corp, R&D Ctr Pharmaceut, Ichon 467810, South Korea
[4] Korea Res Inst Chem Technol, Taejon 305333, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 18期
关键词：
PPAR gamma; indene N-oxide; diabetes; MURAGLITAZAR; MECHANISMS;
D O I：
10.1016/j.bmcl.2007.06.073
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPAR gamma. The best PPAR gamma agonist in this series was 9 h, which showed an EC50 value of 15 nM. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5239 / 5244
页数：6
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