Macrocyclic helix-threading peptides for targeting RNA

被引：62

作者：

Krishnamurthy, Malathy

Simon, Kristina

Orendt, Anita M.

Beal, Peter A.

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

[2] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

[3] Univ Utah, Ctr High Performance Comp, Salt Lake City, UT 84112 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 37期

关键词：

microRNA; peptides; quinolines; ring-closing metathesis; RNA recognition;

D O I：

10.1002/anie.200702247

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hanging on by a thread: RNA-binding macrocyclic helix-threading peptides were synthesized by solid-phase ring-closing metathesis. The cyclic peptide shows improved affinity to a target RNA over its linear precursor. This compound also binds a naturally occurring precursor microRNA target and may be valuable for regulating microRNA function. (Chemical Equation Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：7044 / 7047

页数：4

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