Design and synthesis of phosphinic acids that triply inhibit endothelin converting enzyme, angiotensin converting enzyme and neutral endopeptidase 24.11

被引：39

作者：

McKittrick, BA

Stamford, AW

Weng, XY

Ma, K

Chackalamannil, S

Czarniecki, M

Cleven, RM

Fawzi, AB

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ 07033

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 14期

关键词：

PHOSPHORUS-CONTAINING INHIBITORS; BIG ENDOTHELIN-1; METALLOPROTEINASE INHIBITOR; LUNG; THERMOLYSIN; SUPPRESSES; MEMBRANE; POTENCY; CELLS; ASSAY;

D O I：

10.1016/0960-894X(96)00297-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have synthesized a series of phosphinic acids as inhibitors of a metalloprotease endothelin converting enzyme (ECE). Potent ECE inhibitors 4g and 4o were identified. These compounds are members of a novel class of ECE inhibitors that are also potent inhibitors of angiotensin converting enzyme and neutral endopeptidase. Copyright (C) 1996 Elsevier Science Ltd

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收藏

页码：1629 / 1634

页数：6

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