A biodegradable and biocompatible gecko-inspired tissue adhesive

被引：422

作者：

Mahdavi, Alborz ^{[1
]}

Ferreira, Lino ^{[1
,2
,3
]}

Sundback, Cathryn ^{[4
,7
]}

Nichol, Jason W. ^{[8
]}

Chan, Edwin P. ^{[8
]}

Carter, David J. D. ^{[9
]}

Bettinger, Chris J. ^{[8
]}

Patanavanich, Siamrut ^{[1
]}

Chignozha, Loice ^{[1
]}

Ben-Joseph, Eli ^{[1
]}

Galakatos, Alex ^{[1
]}

Pryor, Howard ^{[4
,7
]}

Pomerantseva, Irina ^{[4
,7
]}

Masiakos, Peter T. ^{[5
,7
]}

Faquin, William ^{[6
,7
]}

Zumbuehl, Andreas ^{[10
]}

Hong, Seungpyo ^{[1
]}

Borenstein, Jeffrey ^{[9
]}

Vacanti, Joseph ^{[4
,5
,7
]}

Langer, Robert ^{[1
,8
]}

Karp, Jeffrey M. ^{[8
,11
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3060197 Cantanhede, Portugal

[3] Biocant Biotechnol Innovat Ctr, P-3060197 Cantanhede, Portugal

[4] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA

[5] Massachusetts Gen Hosp, Dept Pediat Surg, Boston, MA 02114 USA

[6] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[7] Harvard Univ, Sch Med, Boston, MA 02115 USA

[8] Harvard Univ, MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[9] Charles Stark Draper Lab Inc, Cambridge, MA 02139 USA

[10] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

[11] Brigham & Womens Hosp, Ctr Biomed Engn, Boston, MA 02115 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 07期

关键词：

chemical cross-link; medical adhesive; nanotopography; surgical suture; FOOT-HAIR; HYDROGELS; FORCE; SETAE;

D O I：

10.1073/pnas.0712117105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There is a significant medical need for tough biodegradable polymer adhesives that can adapt to or recover from various mechanical deformations while remaining strongly attached to the underlying tissue. We approached this problem by using a polymer poly(glycerol-co-sebacate acrylate) and modifying the surface to mimic the nanotopography of gecko feet, which allows attachment to vertical surfaces. Translation of existing gecko-inspired adhesives for medical applications is complex, as multiple parameters must be optimized, including: biocompatibility, biodegradation, strong adhesive tissue bonding, as well as compliance and conformability to tissue surfaces. Ideally these adhesives would also have the ability to deliver drugs or growth factors to promote healing. As a first demonstration, we have created a gecko-inspired tissue adhesive from a biocompatible and biodegradable elastomer combined with a thin tissue-reactive biocompatible surface coating. Tissue adhesion was optimized by varying dimensions of the nanoscale pillars, including the ratio of tip diameter to pitch and the ratio of tip diameter to base diameter. Coating these nanomolded pillars of biodegradable elastomers with a thin layer of oxidized dextran significantly increased the interfacial adhesion strength on porcine intestine tissue in vitro and in the rat abdominal subfascial in vivo environment. This gecko-inspired medical adhesive may have potential applications for sealing wounds and for replacement or augmentation of sutures or staples.

引用

页码：2307 / 2312

页数：6

共 21 条

[1] Frictional adhesion: a new angle on gecko attachment [J].