The structure and function of γc-dependent cytokines and receptors:: Regulation of T lymphocyte development and homeostasis

被引：74

作者：

He, YW ^{[1
]}

Malek, TR ^{[1
]}

机构：

[1] Univ Miami, Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA

来源：

CRITICAL REVIEWS IN IMMUNOLOGY | 1998年 / 18卷 / 06期

关键词：

immunodeficiency; cytokine receptor superfamily; in vivo animal models; interleukin; 2; 7;

D O I：

10.1615/CritRevImmunol.v18.i6.20

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Five cytokines, IL-2, IL-4, IL-7, IL-9, and IL-15, form one group that is characterized by utilizing the common gamma chain (gamma c) as a receptor subunit. Examination of the phenotype of various cytokine or cytokine receptor "knockout" mice demonstrates that these cytokines are critical for normal lymphocyte development and subsequent functional activity of the peripheral immune compartment. This review summarizes the structural and functional properties of each of these five cytokines and their receptors, including the known redundant pathways for each cytokine or receptor. The contribution of these cytokines and receptors will then be considered in detail with respect to regulation of T lymphocyte development and homeostasis of the peripheral T cell compartment.

引用

页码：503 / 524

页数：22

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