Effect of adrenomedullin administration on acetic acid-induced colitis in rats

被引：38

作者：

Ashizuka, S ^{[1
]}

Ishikawa, N ^{[1
]}

Kato, J ^{[1
]}

Yamaga, J ^{[1
]}

Inatsu, H ^{[1
]}

Eto, T ^{[1
]}

Kitamura, K ^{[1
]}

机构：

[1] Miyazaki Univ, Miyazaki Med Coll, Dept Internal Med 1, Miyazaki 8891692, Japan

来源：

PEPTIDES | 2005年 / 26卷 / 12期

关键词：

acetic acid; adrenomedullin; colitis; inflammatory bowel disease; T helper 2 cells;

D O I：

10.1016/j.peptides.2005.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adrenomedullin (AM) administered intracolonically ameliorated the severity of acetic acid-induced colonic ulceration in rats. Ulcers were induced by subserosal injection of acetic acid into the colon. AM-treated group was administered 0.25-1.0 mu g of AM in 0.5 ml of saline intracolonically once a day; the control group received only saline. AM administration dose-dependently and significantly reduced the size of the ulcerative lesions, the associated edema, and the infiltration of the affected area by inflammatory cells. AM also reduced tissue levels of interleukin-6, but not interferon-gamma. AM reduces the severity of acetic acid-induced colitis in rats, probably by inhibiting the production and/or release of Th-2 cell-derived factors such as interleukin-6. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：2610 / 2615

页数：6

共 35 条

[11] RENAL LOCALIZATION AND ACTIONS OF ADRENOMEDULLIN - A NATRIURETIC PEPTIDE
JOUGASAKI, M
WEI, CM
AARHUS, LL
HEUBLEIN, DM
SANDBERG, SM
BURNETT, JC
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1995, 268 (04) : F657 - F663
[12] ADRENOMEDULLIN - A NOVEL HYPOTENSIVE PEPTIDE ISOLATED FROM HUMAN PHEOCHROMOCYTOMA
KITAMURA, K
KANGAWA, K
KAWAMOTO, M
ICHIKI, Y
NAKAMURA, S
MATSUO, H
ETO, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 192 (02) : 553 - 560
[13] Kojima Ryotaro, 2001, Folia Pharmacologica Japonica, V118, P123, DOI 10.1254/fpj.118.123
[14] The inhibitory effect of adrenomedullin in the rat ileum:: Cross-talk with β3-adrenoceptor in the serotonin-induced muscle contraction
Kravtsov, GM
Hwang, ISS
Tang, F
[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 308 (01) : 241 - 248
[15] Production of adrenomedullin in macrophage cell line and peritoneal macrophage
Kubo, A
Minamino, N
Isumi, Y
Katafuchi, T
Kangawa, K
Dohi, K
Matsuo, H
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (27) : 16730 - 16738
[16] Adrenomedullin receptors: pharmacological features and possible pathophysiological roles
Kuwasako, K
Cao, YN
Nagoshi, Y
Kitamura, K
Eto, T
[J]. PEPTIDES, 2004, 25 (11) : 2003 - 2012
[17] Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease
Ludwiczek, O
Vannier, E
Borggraefe, I
Kaser, A
Siegmund, B
Dinarello, CA
Tilg, H
[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 138 (02) : 323 - 329
[18] EXPERIMENTAL PRODUCTION OF DIFFUSE COLITIS IN RATS
MACPHERSON, BR
PFEIFFER, CJ
[J]. DIGESTION, 1978, 17 (02) : 135 - 150
[19] Fucoidan derived from Cladosiphon okamuranus Tokida ameliorates murine chronic colitis through the down-regulation of interleukin-6 production on colonic epithelial cells
Matsumoto, S
Nagaoka, M
Hara, T
Kimura-Takagi, I
Mistuyama, K
Ueyama, S
[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 136 (03) : 432 - 439
[20] Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis
Millar, AD
Rampton, DS
Chander, CL
Claxson, AWD
Blades, S
Coumbe, A
Panetta, J
Morris, CJ
Blake, DR
[J]. GUT, 1996, 39 (03) : 407 - 415

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