Overlapping genes in vertebrate genomes

被引：80

作者：

Makalowska, I ^{[1
]}

Lin, CF

Makalowski, W

机构：

[1] Penn State Univ, Huck Inst Life Sci, Wartik Lab 502, University Pk, PA 16802 USA

[2] Penn State Univ, Inst Mol Evolutionary Genet, Mueller Lab 512, University Pk, PA 16802 USA

[3] Penn State Univ, Dept Biol, Mueller Lab 512, University Pk, PA 16802 USA

[4] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA

来源：

COMPUTATIONAL BIOLOGY AND CHEMISTRY | 2005年 / 29卷 / 01期

关键词：

overlapping genes; anti-sense; anti-transcript; evolution; genome organization;

D O I：

10.1016/j.compbiolchem.2004.12.006

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Overlapping genes in mammalian genomes are unexpected phenomena even though hundreds of pairs of protein coding overlapping genes have been reported so far. Overlapping genes can be divided into different categories based on direction of transcription as well as on sequence segments being shared between overlapping coding regions. The biologic functions of natural antisense transcripts, their involvement in physiological processes and gene regulation in living organisms are not fully understood. Number of documented examples indicates that they may exert control at various levels of gene expression, such as transcription, mRNA processing, splicing, stability, transport, and translation. Similarly, evolutionary origin of such genes is not known, existing hypotheses can explain only selected cases of mammalian gene overlaps which could originate as result of rearrangements, overprinting and/or adoption of signals in the neighboring gene locus. (c) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1 / 12

页数：12

共 96 条

[1] 2 MAMMALIAN GENES TRANSCRIBED FROM OPPOSITE STRANDS OF THE SAME DNA LOCUS [J].

ADELMAN, JP ;

BOND, CT ;

DOUGLASS, J ;

HERBERT, E .

SCIENCE, 1987, 235 (4795) :1514-1517

[2] Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes [J].

Aparicio, S ;

Chapman, J ;

Stupka, E ;

Putnam, N ;

Chia, J ;

Dehal, P ;

Christoffels, A ;

Rash, S ;

Hoon, S ;

Smit, A ;

Gelpke, MDS ;

Roach, J ;

Oh, T ;

Ho, IY ;

Wong, M ;

Detter, C ;

Verhoef, F ;

Predki, P ;

Tay, A ;

Lucas, S ;

Richardson, P ;

Smith, SF ;

Clark, MS ;

Edwards, YJK ;

Doggett, N ;

Zharkikh, A ;

Tavtigian, SV ;

Pruss, D ;

Barnstead, M ;

Evans, C ;

Baden, H ;

Powell, J ;

Glusman, G ;

Rowen, L ;

Hood, L ;

Tan, YH ;

Elgar, G ;

Hawkins, T ;

Venkatesh, B ;

Rokhsar, D ;

Brenner, S .

SCIENCE, 2002, 297 (5585) :1301-1310

[3] Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D-melanogaster germline [J].

Aravin, AA ;

Naumova, NM ;

Tulin, AV ;

Vagin, VV ;

Rozovsky, YM ;

Gvozdev, VA .

CURRENT BIOLOGY, 2001, 11 (13) :1017-1027

[4]

Armes N, 1996, MOL CELL BIOL, V16, P5591

[5] CLONING OF HUMAN MINERALOCORTICOID RECEPTOR COMPLEMENTARY-DNA - STRUCTURAL AND FUNCTIONAL KINSHIP WITH THE GLUCOCORTICOID RECEPTOR [J].

ARRIZA, JL ;

WEINBERGER, C ;

CERELLI, G ;

GLASER, TM ;

HANDELIN, BL ;

HOUSMAN, DE ;

EVANS, RM .

SCIENCE, 1987, 237 (4812) :268-275

[6] The 5′ region of the COX4 gene contains a novel overlapping gene, NOC4 [J].

Bachman, NJ ;

Wu, W ;

Schmidt, TR ;

Grossman, LI ;

Lomax, MI .

MAMMALIAN GENOME, 1999, 10 (05) :506-512

[7] OVERLAPPING GENES IN BACTERIOPHAGE-PSIX174 [J].

BARRELL, BG ;

AIR, GM ;

HUTCHISON, CA .

NATURE, 1976, 264 (5581) :34-41

[8] The mouse genes for the EP(1) prostanoid receptor and the PKN protein kinase overlap [J].

Batshake, B ;

Sundelin, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 227 (01) :70-76

[9] Shedding light on the dark side of the genome:: Overlapping genes in higher eukaryotes [J].

Boi, S ;

Soldá, G ;

Tenchini, ML .

CURRENT GENOMICS, 2004, 5 (06) :509-524

[10] TENASCIN-X - A NOVEL EXTRACELLULAR-MATRIX PROTEIN ENCODED BY THE HUMAN XB GENE OVERLAPPING P450C21B [J].

BRISTOW, J ;

TEE, MK ;

GITELMAN, SE ;

MELLON, SH ;

MILLER, WL .

JOURNAL OF CELL BIOLOGY, 1993, 122 (01) :265-278

← 1 2 3 4 5 6 7 8 9 10 →