Ubiquitin: Same Molecule, Different Degradation Pathways

被引：411

作者：

Clague, Michael J. ^{[1
]}

Urbe, Sylvie ^{[1
]}

机构：

[1] Univ Liverpool, Inst Translat Med, Liverpool L69 3BX, Merseyside, England

来源：

CELL | 2010年 / 143卷 / 05期

关键词：

ENDOLYSOSOMAL DEGRADATION; PROTEASOME ACTIVITY; CHAINS; AUTOPHAGY; LIGASE; RECOGNITION; P62/SQSTM1; COMPLEX; SIGNAL;

D O I：

10.1016/j.cell.2010.11.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ubiquitin is a common demoninator in the targeting of substrates to all three major protein degradation pathways in mammalian cells: the proteasome, the lysosome, and the autophagosome. The factors that direct a substrate toward a particular route of degradation likely include ubiquitin chain length and linkage type, which may favor interaction with particular receptors or confer differential susceptibility to deubiquitinase activities associated with each pathway.

引用

页码：682 / 685

页数：4

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