The protective effect of different enteral nutrition combined with growth hormone on intestinal mucosal damage of scalded rats

被引：14

作者：

Guo, Guanghua ^{[1
]}

Bai, Xiangjun ^{[1
]}

Cai, Chen ^{[2
]}

Zhang, Jun ^{[3
]}

Li, Xin ^{[3
]}

Zhu, Feng ^{[1
]}

Liang, Shangdong ^{[3
]}

机构：

[1] Huazhong Univ Sci & Technol, Affiliated Tongji Hosp, Tongji Med Coll, Dept Traumat Surg, Wuhan 430030, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 1, Dept Burns, Hefei 230000, Anhui, Peoples R China

[3] Nanchang Univ, Basic Med Coll, Dept Physiol, Nanchang 330006, Jiangxi, Peoples R China

来源：

BURNS | 2010年 / 36卷 / 08期

关键词：

Burn; Enteral nutrition; Enteral immune nutrition; Recombinant human; Growth hormone; PARENTERAL-NUTRITION; BACTERIAL TRANSLOCATION; BURN PATIENTS; GLUTAMINE; IMMUNITY; INJURY;

D O I：

10.1016/j.burns.2010.04.003

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Objective To investigate the protective effect of standard enteral nutrition (EN) and enteral immunonutrition (EIN) combined with recombinant human growth hormone rhGH on intestinal mucosa damage in scalded rats Methods Rats subjected to 30% total body surface area (TBSA III) and they were divided randomly into five groups referred to as EN EIN EN + rhGH EIN + rhGH and control groups After injury on days 1 4 7 and 10 venous blood and intestinal mucus were collected to monitor the level of serum endotoxin tumor necrosis factor alpha (TNF alpha) and the concentration of intestinal mucus s IgA The number of IgA plasma cells in intestinal tissue and proliferating cell nuclear antigen (PCNA) in intestinal mucosa were detected using the method of immunohistochemistry Results After injury on days 4 7 and 10 PCNA value of the intestinal mucosa the number of IgA plasma cells in intestinal lamina and the concentration of intestinal mucus s IgA in EIN and EN + rhGH groups are significantly increased compared with those in EN group (P < 0 05 or P < 0 01) but serum endotoxin and TNF alpha levels are reduced than those in EN group After injury on days 4 7 and 10 PCNA values propria IgA plasma cell number and s IgA concentra ton in EIN + rhGH group have no significant difference compared with those in EIN group (P > 0 05) while the serum endotoxin and TNF alpha levels are lower than those in EIN group Conclusions EN or EIN combined with rhGH has the additional effect on treatment to reduce intestinal mucosa damage of scalded rats and strengthen the protection of intestinal mucosa damage Crown Copyright (C) 2010 Published by Elsevier Ltd and ISBI All rights reserved

引用

页码：1283 / 1288

页数：6

共 22 条

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[2]

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