Spatially Gradated Hydrogel Platform as a 3D Engineered Tumor Microenvironment

被引：93

作者：

Pedron, Sara ^{[1
]}

Becka, Eftalda ^{[1
]}

Harley, Brendan A. ^{[2
]}

机构：

[1] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA

[2] Univ Illinois, Inst Genom Biol, Dept Chem & Biomol Engn, Roger Adams Lab 110, Urbana, IL 61801 USA

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 09期

基金：

美国国家科学基金会;

关键词：

STEM-CELL CULTURE; GLIOBLASTOMA CELLS; MATRICES; MATRIX-METALLOPROTEINASE-9; HETEROGENEITY; GENERATION; ADHESION; MODELS;

D O I：

10.1002/adma.201404896

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

There is an acute need for biomaterial tools that recreate the heterogeneous brain-tumor microenvironment. A microfluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor-inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the potential for clinical insight.

引用

收藏

页码：1567 / +

页数：7

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