Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents

被引:61
作者
Habermann, J [1 ]
Ley, SV [1 ]
Scott, JS [1 ]
机构
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 19期
关键词
D O I
10.1039/a805997g
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Polymer-supported reagents and other solid sequestering agents may be used to generate a library of piperidino-thiomorpholine derivatives without any chromatographic purification steps.
引用
收藏
页码:3127 / 3130
页数:4
相关论文
共 26 条
[1]   SPECTRAL AND CHEMICAL-PROPERTIES OF DIMETHYLDIOXIRANE AS DETERMINED BY EXPERIMENT AND ABINITIO CALCULATIONS [J].
ADAM, W ;
CHAN, YY ;
CREMER, D ;
GAUSS, J ;
SCHEUTZOW, D ;
SCHINDLER, M .
JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (13) :2800-2803
[2]   APPLICATION OF FUNCTIONALIZED POLYMERS IN ORGANIC-SYNTHESIS [J].
AKELAH, A ;
SHERRINGTON, DC .
CHEMICAL REVIEWS, 1981, 81 (06) :557-587
[3]   Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity [J].
Barbachyn, MR ;
Hutchinson, DK ;
Brickner, SJ ;
Cynamon, MH ;
Kilburn, JO ;
Klemens, SP ;
Glickman, SE ;
Grega, KC ;
Hendges, SK ;
Toops, DS ;
Ford, CW ;
Zurenko, GE .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (03) :680-685
[4]   ONE POT SOLID-PHASE CLEAVAGE OF ALPHA-DIOLS TO PRIMARY ALCOHOLS - AN ATTRACTIVE ROUTE TO TRIHYDROXY-NUCLEOSIDES, ANTIVIRAL PRECURSORS [J].
BESSODES, M ;
ANTONAKIS, K .
TETRAHEDRON LETTERS, 1985, 26 (10) :1305-1306
[5]   Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to β-hydroxyamines [J].
Bolli, MH ;
Ley, SV .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (15) :2243-2246
[6]  
BONGINI A, 1980, SYNTHESIS-STUTTGART, P143
[7]   POLYMER-SUPPORTED PHOSPHONATES - OLEFINS FROM ALDEHYDES, KETONES, AND DIOXOLANS BY MEANS OF POLYMER-SUPPORTED PHOSPHONATES [J].
CAINELLI, G ;
CONTENTO, M ;
MANESCALCHI, F ;
REGNOLI, R .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1980, (11) :2516-2519
[8]   Combinatorial synthesis of dihydropyridone libraries and their derivatives [J].
Creswell, MW ;
Bolton, GL ;
Hodges, JC ;
Meppen, M .
TETRAHEDRON, 1998, 54 (16) :3983-3998
[9]  
Flynn D L, 1998, Curr Opin Drug Discov Devel, V1, P41
[10]   Chemical library purification strategies based on principles of complementary molecular reactivity and molecular recognition [J].
Flynn, DL ;
Crich, JZ ;
Devraj, RV ;
Hockerman, SL ;
Parlow, JJ ;
South, MS ;
Woodard, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (21) :4874-4881