Using a novel plug flow reactor for the in situ, simultaneous, monitoring of SAXS and WAXD during crystallisation from solution

被引：23

作者：

Alison, HG

Davey, RJ

Garside, J

Quayle, MJ

Tiddy, GJT

Clarke, DT

Jones, GR

机构：

[1] UMIST, Dept Chem Engn, Mol Mat Ctr, Manchester M60 1QD, Lancs, England

[2] SERC, Daresbury Lab, Warrington WA4 4AD, Cheshire, England

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2003年 / 5卷 / 22期

关键词：

D O I：

10.1039/b309309c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The design and application of a novel plug flow crystalliser is described. Simultaneous collection of SAXS and WAXD during the nucleation and crystal growth of a small organic molecule from solution is reported. Preliminary data imply the separation of a non-diffracting phase prior to the appearance of crystalline solid.

引用

页码：4998 / 5000

页数：3

共 11 条

[1]

ALISON HG, 2002, THESIS UMIST MANCHES

[2] Computer simulation of crystallization from solution [J].

Anwar, J ;

Boateng, PK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (37) :9600-9604

[3] Solution crystallisation via a submerged liquid-liquid phase boundary:: oiling out [J].

Bonnett, PE ;

Carpenter, KJ ;

Dawson, S ;

Davey, RJ .

CHEMICAL COMMUNICATIONS, 2003, (06) :698-699

[4] Crystal engineering - nucleation, the key step [J].

Davey, RJ ;

Allen, K ;

Blagden, N ;

Cross, WI ;

Lieberman, HF ;

Quayle, MJ ;

Righini, S ;

Seton, L ;

Tiddy, GJT .

CRYSTENGCOMM, 2002, 4 :257-264

[5]

Gavezzotti A, 1999, CHEM-EUR J, V5, P567, DOI 10.1002/(SICI)1521-3765(19990201)5:2<567::AID-CHEM567>3.0.CO

[6]

2-6

[7]

Lindner P., 2002, NEUTRONS XRAYS LIGHT

[8] Crystal nucleation in simple and complex fluids [J].

Oxtoby, DW .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2003, 361 (1804) :419-427

[9]

Quayle MJ, 2002, PHYS CHEM CHEM PHYS, V4, P416, DOI 10.1039/bIO8773h

[10] MIXING LIQUIDS IN MICROSECONDS [J].

REGENFUSS, P ;

CLEGG, RM ;

FULWYLER, MJ ;

BARRANTES, FJ ;

JOVIN, TM .

REVIEW OF SCIENTIFIC INSTRUMENTS, 1985, 56 (02) :283-290

← 1 2 →