Solution crystallisation via a submerged liquid-liquid phase boundary:: oiling out

被引：164

作者：

Bonnett, PE

Carpenter, KJ

Dawson, S

Davey, RJ

机构：

[1] UMIST, Dept Chem Engn, Mol Mat Ctr, Manchester M60 1QD, Lancs, England

[2] Syngenta, Proc Studies Grp, Huddersfield HD2 1FF, W Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 06期

关键词：

D O I：

10.1039/b212062c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In many situations the process of crystallisation from solution is known to occur via metastable crystalline states (polymorphs or solvates). Here we present what we believe to be a novel example of small molecule crystallisation in which the initial separation of a solute rich liquid phase precedes the crystallisation event. We believe this occurs because a submerged liquid-liquid phase boundary is accessible within the metastable zone of the crystal nucleation process.

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收藏

页码：698 / 699

页数：2

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