Merrifield MicroTube™ reactors for solid phase synthesis

被引：23

作者：

Li, RS ^{[1
]}

Xiao, XY ^{[1
]}

Czarnik, AW ^{[1
]}

机构：

[1] IRORI, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(98)01963-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polystyrene grafted polypropylene MicroTube(TM) reactors (length x OD, 25 x 5 mm) have been functionalized with chloromethyl groups (Merrifield-type) using chloromethyl methyl ether and Lewis acid catalysts. A potentiometric method using a chloride ion selective electrode has been developed to measure the loading of the Merrifield MicroTube(TM) reactors. A typical loading of 25-35 mu mol/tube for Merrifield MicroTube(TM) reactors has been achieved. Several reactions performed on Merrifield MicroTube(TM) reactors demonstrated that they are excellent supports for solid phase synthesis. As a result of the ease with which radiofrequency memory tags can be associated with and separated from the supports, these MicroTube(TM) reactors can facilitate the synthesis of combinatorial libraries. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：8581 / 8584

页数：4

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