Effect of lifestyle intervention on the occurrence of metabolic syndrome and its components in the Finnish Diabetes Prevention Study

被引：148

作者：

Ilanne-Parikka, Pirjo ^{[1
,2
]}

Eriksson, Johan G. ^{[3
,4
]}

Lindstrom, Jaana ^{[3
]}

Peltonen, Markku ^{[3
]}

Aunola, Sirkka ^{[5
]}

Hamalainen, Helena ^{[6
]}

Keinanen-Kiukaanniemi, Sirkka ^{[7
,8
,9
]}

Laakso, Mauri ^{[7
,8
,10
]}

Valle, Timo T. ^{[3
]}

Lahtela, Jorma ^{[11
]}

Uusitupa, Matti ^{[12
]}

Tuomilehto, Jaakko ^{[3
,4
]}

机构：

[1] Finnish Diabet Associat, Ctr Diabet, Tampere, Finland

[2] Pirkanmaa Hosp Dist, Dept Res Adm, Tampere, Finland

[3] Natl Publ Hlth Inst, Diabet Unit, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland

[4] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland

[5] Natl Inst Publ Hlth, Lab Populat Res, Dept Hlth & Funct Capac, Turku, Finland

[6] Social Insurance Inst, Res Dept, Turku, Finland

[7] Univ Oulu, Dept Publ Hlth Sci & Gen Practice, Oulu, Finland

[8] Oulu Deaconess Inst, Dept Sport Med, Oulu, Finland

[9] Oulu Hlth Ctr, Oulu, Finland

[10] Oulu Univ Hosp, Unit Gen Practice, Oulu, Finland

[11] Tampere Univ Hosp, Dept Internal Med, Tampere, Finland

[12] Univ Kuopio, Dept Publ Hlth & Clin Nutr, FIN-70211 Kuopio, Finland

来源：

DIABETES CARE | 2008年 / 31卷 / 04期

关键词：

D O I：

10.2337/dc07-1117

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - The aim of this secondary analysis of the Finnish Diabetes Prevention Study was to assess the effects of lifestyle intervention on metabolic syndrome and its components. RESEARCH DESIGN AND METHODS - A total of 522 middle-aged overweight men and women with impaired glucose tolerance were randomized into an individualized lifestyle intervention group or a standard care control group. National Cholesterol Education Program criteria were used for the definition of metabolic syndrome. RESULTS - At the end of the study, with a mean follow-up of 3.9 years, we found a significant reduction in the prevalence of metabolic syndrome in the intervention group compared with the control group (odds ratio [OR] 0.62 [95% CI 0.40-0.95]) and in the prevalence of abdominal obesity (0.48 [0.28-0.81]). CONCLUSIONS - The results suggest that lifestyle intervention may also reduce risk of cardiovascular disease in the long run.

引用

页码：805 / 807

页数：3

共 14 条

[1] Metabolic syndrome - a new world-wide definition. A consensus statement from the international diabetes federation [J].

Alberti, KGMM ;

Zimmet, P ;

Shaw, J .

DIABETIC MEDICINE, 2006, 23 (05) :469-480

[2]

Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO

[3]

2-S

[4] The metabolic syndrome [J].

Eckel, RH ;

Grundy, SM ;

Zimmet, PZ .

LANCET, 2005, 365 (9468) :1415-1428

[5] Prevention of Type II diabetes in subjects with impaired glucose tolerance:: the Diabetes Prevention Study (DPS) in Finland -: Study design and 1-year interim report on the feasibility of the lifestyle intervention programme [J].

Eriksson, J ;

Lindström, J ;

Valle, T ;

Aunola, S ;

Hämäläinen, H ;

Ilanne-Parikka, P ;

Keinänen-Kiukaanniemi, S ;

Laakso, M ;

Lauhkonen, M ;

Lehto, P ;

Lehtonen, A ;

Louheranta, A ;

Mannelin, M ;

Martikkala, V ;

Rastas, M ;

Sundvall, J ;

Turpeinen, A ;

Viljanen, T ;

Uusitupa, M ;

Tuomilehto, J .

DIABETOLOGIA, 1999, 42 (07) :793-801

[6] Diagnosis and management of the metabolic syndrome - An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement [J].

Grundy, SM ;

Cleeman, JI ;

Daniels, SR ;

Donato, KA ;

Eckel, RH ;

Franklin, BA ;

Gordon, DJ ;

Krauss, RM ;

Savage, PJ ;

Smith, SC ;

Spertus, JA ;

Costa, F .

CIRCULATION, 2005, 112 (17) :2735-2752

[7]

Knowler WC, 2002, NEW ENGL J MED, V346, P393, DOI 10.1056/NEJMoa012512

[8] The Finnish Diabetes Prevention Study (DPS) [J].

Lindstrom, J ;

Louheranta, A ;

Mannelin, M ;

Rastas, M ;

Salminen, V ;

Eriksson, J ;

Uusitupa, M ;

Tuomilehto, J .

DIABETES CARE, 2003, 26 (12) :3230-3236

[9] The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: The diabetes prevention program randomized trial [J].

Orchard, TJ ;

Temprosa, M ;

Goldberg, R ;

Haffner, S ;

Ratner, R ;

Marcovina, S ;

Fowler, S .

ANNALS OF INTERNAL MEDICINE, 2005, 142 (08) :611-619

[10] Predictors of the incident metabolic syndrome in adults - The Insulin Resistance Atherosclerosis Study [J].

Palaniappan, L ;

Carnethon, MR ;

Wang, Y ;

Hanley, AJG ;

Fortmann, SP ;

Haffner, SM ;

Wagenknecht, L .

DIABETES CARE, 2004, 27 (03) :788-793

← 1 2 →