A "cephalosporin-like" cyclic depsipeptide:: Synthesis and reaction with β-lactam-recognizing enzymes

被引：5

作者：

Adediran, SA ^{[1
]}

Cabaret, D

Pratt, RF

Wakselman, M

机构：

[1] Wesleyan Univ, Dept Chem, Middletown, CT 06459 USA

[2] Univ Versailles, SIRCOB, F-78000 Versailles, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(98)00739-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The cyclic depsipeptide 8-carboxy-3-phenylacetamido-3,4-dihydro-2H-1-benzopyran-2-one a cyclic analog of aryl phenaceturates with structural similarity to cephalosporins, has been synthesized as a potential substrate/inhibitor of beta-lactam-recognizing enzymes. It was found to be a tight-binding, poor substrate of class A beta-lactamases and an irreversible inhibitor of several DD-peptidases. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：341 / 346

页数：6

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