Immunological tolerance in germinal centres

被引：57

作者：

Pulendran, B

vanDriel, R

Nossal, GJV

机构：

[1] ALFRED HOSP,MONASH MED SCH,DEPT PATHOL & IMMUNOL,PRAHRAN,VIC 3181,AUSTRALIA

[2] PO ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,PARKVILLE,VIC 3050,AUSTRALIA

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 01期

关键词：

D O I：

10.1016/S0167-5699(97)80011-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability to avoid autoimmunity is a cardinal feature of the immune system. In healthy individuals, this is achieved by several mechanisms that exclude self-reactive lymphocytes from mature lymphocyte repertoires. Here, Bali Pulendran, Rosemary van Driel and G.J.V. Nossal review recent studies indicating that several mechanisms of self-tolerance operate in germinal centres.

引用

页码：27 / 32

页数：6

共 65 条

[1] TIMING, GENETIC REQUIREMENTS AND FUNCTIONAL CONSEQUENCES OF SOMATIC HYPERMUTATION DURING B-CELL DEVELOPMENT [J].

ALLEN, D ;

CUMANO, A ;

DILDROP, R ;

KOCKS, C ;

RAJEWSKY, K ;

RAJEWSKY, N ;

ROES, J ;

SABLITZKY, F ;

SIEKEVITZ, M .

IMMUNOLOGICAL REVIEWS, 1987, 96 :5-22

[2] GENERATION OF MEMORY B-CELLS AND PLASMA-CELLS IN-VITRO [J].

ARPIN, C ;

DECHANET, J ;

VANKOOTEN, C ;

MERVILLE, P ;

GROUARD, G ;

BRIERE, F ;

BANCHEREAU, J ;

LIU, YJ .

SCIENCE, 1995, 268 (5211) :720-722

[3] MATURATION OF THE IMMUNE-RESPONSE IN GERMINAL-CENTERS [J].

BEREK, C ;

BERGER, A ;

APEL, M .

CELL, 1991, 67 (06) :1121-1129

[4] CONTROL OF AUTOANTIBODY AFFINITY BY SELECTION AGAINST AMINO-ACID REPLACEMENTS IN THE COMPLEMENTARITY-DETERMINING REGIONS [J].

BORRETZEN, M ;

RANDEN, I ;

ZDARSKY, E ;

FORRE, O ;

NATVIG, JB ;

THOMPSON, KM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (26) :12917-12921

[5]

BUDTZ PE, 1989, CELL TISSUE RES, V256, P475

[6]

CAULFIELD MJ, 1987, J IMMUNOL, V138, P3680

[7] CELLULAR SITES OF IMMUNOLOGIC UNRESPONSIVENESS [J].

CHILLER, JM ;

HABICHT, GS ;

WEIGLE, WO .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1970, 65 (03) :551-&

[8] THE ROLE OF SOMATIC MUTATION IN THE PATHOGENIC ANTI-DNA RESPONSE [J].

DIAMOND, B ;

KATZ, JB ;

PAUL, E ;

ARANOW, C ;

LUSTGARTEN, D ;

SCHARFF, MD .

ANNUAL REVIEW OF IMMUNOLOGY, 1992, 10 :731-757

[9]

DINTZIS HM, 1992, P NATL ACAD SCI USA, V89, P113

[10]

DRESSER DW, 1962, IMMUNOLOGY, V5, P161

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