Immunological tolerance in germinal centres

被引:57
作者
Pulendran, B
vanDriel, R
Nossal, GJV
机构
[1] ALFRED HOSP,MONASH MED SCH,DEPT PATHOL & IMMUNOL,PRAHRAN,VIC 3181,AUSTRALIA
[2] PO ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,PARKVILLE,VIC 3050,AUSTRALIA
来源
IMMUNOLOGY TODAY | 1997年 / 18卷 / 01期
关键词
D O I
10.1016/S0167-5699(97)80011-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The ability to avoid autoimmunity is a cardinal feature of the immune system. In healthy individuals, this is achieved by several mechanisms that exclude self-reactive lymphocytes from mature lymphocyte repertoires. Here, Bali Pulendran, Rosemary van Driel and G.J.V. Nossal review recent studies indicating that several mechanisms of self-tolerance operate in germinal centres.
引用
收藏
页码:27 / 32
页数:6
相关论文
共 65 条
[41]   ANTIGEN-DRIVEN SELECTION OF VIRGIN AND MEMORY B-CELLS [J].
MACLENNAN, ICM ;
GRAY, D .
IMMUNOLOGICAL REVIEWS, 1986, 91 :61-85
[42]   THE FOLLICULAR DENDRITIC CELL - LONG-TERM ANTIGEN RETENTION DURING IMMUNITY [J].
MANDEL, TE ;
PHIPPS, RP ;
ABBOT, A ;
TEW, JG .
IMMUNOLOGICAL REVIEWS, 1980, 53 :29-59
[43]   MOLECULAR CHARACTERIZATION OF SINGLE MEMORY B-CELLS [J].
MCHEYZERWILLIAMS, MG ;
NOSSAL, GJV ;
LALOR, PA .
NATURE, 1991, 350 (6318) :502-505
[44]   ANTIGEN-DRIVEN B-CELL DIFFERENTIATION INVIVO [J].
MCHEYZERWILLIAMS, MG ;
MCLEAN, MJ ;
LALOR, PA ;
NOSSAL, GJV .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (01) :295-307
[45]  
MILLER JFAP, 1992, ANNU REV IMMUNOL, V10, P51, DOI 10.1146/annurev.immunol.10.1.51
[46]   T-B CELL-INTERACTION INHIBITS SPONTANEOUS APOPTOSIS OF MATURE LYMPHOCYTES IN BCL-2-DEFICIENT MICE [J].
NAKAYAMA, KI ;
NAKAYAMA, K ;
DUSTIN, LB ;
LOH, DY .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (04) :1101-1109
[47]   CELLULAR AND MOLECULAR MECHANISMS OF B-LYMPHOCYTE TOLERANCE [J].
NOSSAL, GJV .
ADVANCES IN IMMUNOLOGY, 1992, 52 :283-331
[48]   CELLULAR MECHANISMS OF IMMUNOLOGICAL-TOLERANCE [J].
NOSSAL, GJV .
ANNUAL REVIEW OF IMMUNOLOGY, 1983, 1 :33-62
[49]   SOLUBLE-ANTIGEN PROFOUNDLY REDUCES MEMORY B-CELL NUMBERS EVEN WHEN GIVEN AFTER CHALLENGE IMMUNIZATION [J].
NOSSAL, GJV ;
KARVELAS, M ;
PULENDRAN, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) :3088-3092
[50]   SOLUBLE-ANTIGEN ABROGATES THE APPEARANCE OF ANTI-PROTEIN IGG1-FORMING CELL PRECURSORS DURING PRIMARY IMMUNIZATION [J].
NOSSAL, GJV ;
KARVELAS, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1615-1619