Physical and functional interaction of the Werner syndrome protein with poly-ADP ribosyl transferase

被引：22

作者：

Adelfalk, C ^{[1
]}

Kontou, M ^{[1
]}

Hirsch-Kauffmann, M ^{[1
]}

Schweiger, M ^{[1
]}

机构：

[1] Free Univ Berlin, Dept Biochem, D-14195 Berlin, Germany

来源：

FEBS LETTERS | 2003年 / 554卷 / 1-2期

关键词：

Werner's syndrome; WRN; poly-ADP ribosyl transferase; ADP-ribosylation;

D O I：

10.1016/S0014-5793(03)01088-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Werner's syndrome is a rare disease of premature ageing. The WRN gene product defective in this disorder belongs to the RecQ helicase family and is thought to be involved in DNA metabolism. Another protein, which plays an important role in both DNA replication and repair, is the poly-ADP ribosyl transferase. Here we demonstrate an interaction of these two proteins resulting in ADP-ribosylation of the WRN protein. These results imply that WRN is involved in DNA replication and in DNA repair. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：55 / 58

页数：4

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