A gene map of the human genome

被引：880

作者：

Schuler, GD

Boguski, MS

Stewart, EA

Stein, LD

Gyapay, G

Rice, K

White, RE

RodriguezTome, P

Aggarwal, A

Bajorek, E

Bentolila, S

Birren, BB

Butler, A

Castle, AB

Chiannilkulchai, N

Chu, A

Clee, C

Cowles, S

Day, PJR

Dibling, T

Drouot, N

Dunham, I

Duprat, S

East, C

Edwards, C

Fan, JB

Fang, N

Fizames, C

Garrett, C

Green, L

Hadley, D

Harris, M

Harrison, P

Brady, S

Hicks, A

Holloway, E

Hui, L

Hussain, S

LouisDitSully, C

Ma, J

MacGilvery, A

Mader, C

Maratukulam, A

Matise, TC

McKusick, KB

Morissette, J

Mungall, A

Muselet, D

Nusbaum, HC

Page, DC

机构：

[1] STANFORD UNIV, SCH MED, CTR HUMAN GENOME, DEPT GENET, STANFORD, CA 94305 USA

[2] MIT, WHITEHEAD INST BIOMED RES, CTR GENOME RES, CAMBRIDGE, MA 02142 USA

[3] GENETHON, CNRS, URA 1922, F-91000 EVRY, FRANCE

[4] SANGER CTR, HINXTON CB10 1SA, CAMBRIDGE, ENGLAND

[5] UNIV OXFORD, WELLCOME TRUST CTR HUMAN GENET, NUFFIELD DEPT CLIN MED, OXFORD OX3 7BN, ENGLAND

[6] ROCKEFELLER UNIV, LAB STAT GENET, NEW YORK, NY 10021 USA

[7] CHU LAVAL, CTR RECH, ST FOY, PQ G1V 4G2, CANADA

[8] INST GENOM RES, ROCKVILLE, MD 20850 USA

[9] EUROPEAN MOL BIOL LAB OUTSTN, EUROPEAN BIOINFORMAT INST, CAMBRIDGE CB10 1SD, ENGLAND

[10] CNRS, UPR 420, F-94801 VILLEJUIF, FRANCE

[11] UNIV COLORADO, HLTH SCI CTR, DEPT PHARMACOL, DENVER, CO 80262 USA

[12] UNIV COLORADO, HLTH SCI CTR, PROGRAM MOL BIOL, DENVER, CO 80262 USA

[13] NIH, NATL CTR HUMAN GENOME RES, LAB GENET DIS RES, BETHESDA, MD 20892 USA

[14] UNIV CAMBRIDGE, DEPT GENET, CAMBRIDGE CB2 3EH, ENGLAND

[15] RES GENET INC, HUNTSVILLE, AL 35801 USA

[16] KAZUSA DNA RES INST, CHIBA 292, JAPAN

[17] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA

[18] MCGILL UNIV, DEPT MED, MONTREAL, PQ H3G 1A4, CANADA

[19] MCGILL UNIV, DEPT HUMAN GENET, MONTREAL, PQ H3G 1A4, CANADA

[20] MCGILL UNIV, MONTREAL GEN HOSP, RES INST, MONTREAL, PQ H3G 1A4, CANADA

来源：

SCIENCE | 1996年 / 274卷 / 5287期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/science.274.5287.540

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. The integrated resource is available through a site on the World Wide Web al http://www.ncbi.nlm.nih.gov/SCIENCE96/.

引用

页码：540 / 546

页数：7

共 62 条

[11] Yeast genes and human disease [J].