Thyrotropin secreting pituitary adenoma effectively treated with octreotide

被引：8

作者：

Fukuda, T ^{[1
]}

Yokoyama, N ^{[1
]}

Tamai, M ^{[1
]}

Imaizumi, M ^{[1
]}

Kimura, H ^{[1
]}

Tominaga, T ^{[1
]}

Ashizawa, K ^{[1
]}

Kiriyama, T ^{[1
]}

Yoshimine, H ^{[1
]}

Ohishi, K ^{[1
]}

Eguchi, K ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Internal Med 1, Nagasaki 8528501, Japan

来源：

INTERNAL MEDICINE | 1998年 / 37卷 / 12期

关键词：

somatostatin analog; tumor shrinkage; syndrome of inappropriate TSH secretion (SITSH);

D O I：

10.2169/internalmedicine.37.1027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a 65-year-old woman with thyrotropin (TSH) secreting pituitary adenoma, who was diagnosed based on the lack of inhibition of serum TSH despite an increased serum free thyroxine (T-4), a low response of serum TSH to thyrotropin releasing hormone, and a pituitary tumor as revealed by magnetic resonance imaging. The pituitary adenoma was, however, inoperable due to chronic respiratory failure. The treatment with octreotide in a dose of 100 mu g b.i.d. resulted in inhibition of serum TSH and free T-4 to euthyroid levels and considerable shrinkage of the pituitary tumor. These effects were continued over 8 months after the start of octreotide therapy without any adverse effects. These findings add further evidence that octreotide is useful for treating inoperable TSH secreting pituitary adenoma.

引用

页码：1027 / 1030

页数：4

共 22 条

[1] THYROTROPIN-SECRETING PITUITARY-ADENOMAS - REPORT OF 7 CASES [J].

BECKERS, A ;

ABS, R ;

MAHLER, C ;

VANDALEM, JL ;

PIRENS, G ;

HENNEN, G ;

STEVENAERT, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (02) :477-483

[2] INHIBITION OF CELL-PROLIFERATION BY THE SOMATOSTATIN ANALOG RC-160 IS MEDIATED BY SOMATOSTATIN RECEPTOR SUBTYPES SSTR2 AND SSTR5 THROUGH DIFFERENT MECHANISMS [J].

BUSCAIL, L ;

ESTEVE, JP ;

SAINTLAURENT, N ;

BERTRAND, V ;

REISINE, T ;

OCARROLL, AM ;

BELL, GI ;

SCHALLY, AV ;

VAYSSE, N ;

SUSINI, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) :1580-1584

[3] STIMULATION OF TYROSINE PHOSPHATASE AND INHIBITION OF CELL-PROLIFERATION BY SOMATOSTATIN ANALOGS - MEDIATION BY HUMAN SOMATOSTATIN RECEPTOR SUBTYPES SSTR1 AND SSTR2 [J].

BUSCAIL, L ;

DELESQUE, N ;

ESTEVE, JP ;

SAINTLAURENT, N ;

PRATS, H ;

CLERC, P ;

ROBBERECHT, P ;

BELL, GI ;

LIEBOW, C ;

SCHALLY, AV ;

VAYSSE, N ;

SUSINI, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (06) :2315-2319

[4] OCTREOTIDE THERAPY FOR THYROID-STIMULATING HORMONE-SECRETING PITUITARY-ADENOMAS - A FOLLOW-UP OF 52 PATIENTS [J].

CHANSON, P ;

WEINTRAUB, BD ;

HARRIS, AG .

ANNALS OF INTERNAL MEDICINE, 1993, 119 (03) :236-240

[5] TREATMENT OF THYROID-STIMULATING HORMONE-SECRETING ADENOMAS WITH OCTREOTIDE [J].

CHANSON, P ;

WARNET, A .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1992, 41 (09) :62-65

[6] INAPPROPRIATE SECRETION OF THYROTROPIN BY THE PITUITARY [J].

FAGLIA, G ;

BECKPECCOZ, P ;

PISCITELLI, G ;

MEDRI, G .

HORMONE RESEARCH, 1987, 26 (1-4) :79-99

[7] OCTREOTIDE CHANGES SERUM THYROTROPIN (TSH) GLYCOISOMER DISTRIBUTION AS ASSESSED BY LECTIN CHROMATOGRAPHY IN A TSH MACROADENOMA PATIENT [J].

FRANCIS, TB ;

SMALLRIDGE, RC ;

KANE, J ;

MAGNER, JA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (01) :183-187

[8]

Greenman Yona, 1995, P546

[9] CALCIUM DEPOSITION IN HUMAN PITUITARY-ADENOMAS STUDIED BY HISTOLOGY, ELECTRON-MICROSCOPY, ELECTRON-DIFFRACTION AND X-RAY SPECTROMETRY [J].

ILSE, G ;

RYAN, N ;

KOVACS, K ;

ILSE, D .

EXPERIMENTELLE PATHOLOGIE, 1980, 18 (7-8) :377-386

[10]

Kourides I A, 1994, Curr Ther Endocrinol Metab, V5, P48

← 1 2 3 →