Motor fluctuations and dyskinesia in Parkinson's disease

被引:90
作者
Nutt, JG [1 ]
机构
[1] Oregon Hlth Sci Univ, Sch Med, Dept Neurol, Portland, OR 97201 USA
[2] Oregon Hlth Sci Univ, Sch Med, Dept Physiol & Pharmacol, Portland, OR 97201 USA
关键词
Parkinson's disease; levodopa; motor fluctuations; levodopa-induced dyskinesia;
D O I
10.1016/S1353-8020(01)00024-4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Motor fluctuations and dyskinesia are common complications of long-term levodopa therapy. The neural and molecular mechanisms underlying their development are partially understood. A variety of clinical strategies may reduce the unpredictability of motor fluctuations and reduce their impact. Prevention of these complications remains an elusive goal. (C) 2001 Published by Elsevier Science Ltd.
引用
收藏
页码:101 / 108
页数:8
相关论文
共 71 条
[31]   Usefulness of pallidotomy in advanced Parkinson's disease [J].
Johansson, F ;
Malm, J ;
Nordh, E ;
Hariz, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1997, 62 (02) :125-132
[32]   THE ROLE OF L-DOPA HOLIDAY IN THE LONG-TERM MANAGEMENT OF PARKINSONS-DISEASE [J].
KAYE, JA ;
FELDMAN, RG .
CLINICAL NEUROPHARMACOLOGY, 1986, 9 (01) :1-13
[33]   COMPARISON OF MOTOR RESPONSE TO APOMORPHINE AND LEVODOPA IN PARKINSONS-DISEASE [J].
KEMPSTER, PA ;
FRANKEL, JP ;
STERN, GM ;
LEES, AJ .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1990, 53 (11) :1004-1007
[34]   EARLY DEVELOPMENT OF LEVODOPA-INDUCED DYSKINESIAS AND RESPONSE FLUCTUATIONS IN YOUNG-ONSET PARKINSONS-DISEASE [J].
KOSTIC, V ;
PRZEDBORSKI, S ;
FLASTER, E ;
STERNIC, N .
NEUROLOGY, 1991, 41 (02) :202-205
[35]   Posteroventral medial pallidotomy in advanced Parkinson's disease [J].
Lang, AE ;
Lozano, AM ;
Montgomery, E ;
Duff, J ;
Tasker, R ;
Hutchinson, W .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (15) :1036-1042
[36]  
LANGSTON JW, 1984, CAN J NEUROL SCI, V11, P160
[37]  
LEVY G, 1966, CLIN PHARMACOL THER, V7, P362
[38]   Clinical evaluation of pramipexole in advanced Parkinson's disease: Results of a double-blind, placebo-controlled, parallel-group study [J].
Lieberman, A ;
Ranhosky, A ;
Korts, D .
NEUROLOGY, 1997, 49 (01) :162-168
[39]   Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease [J].
Limousin, P ;
Krack, P ;
Pollak, P ;
Benazzouz, A ;
Ardouin, C ;
Hoffmann, D ;
Benabid, AL .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (16) :1105-1111
[40]   EFFECT ON PARKINSONIAN SIGNS AND SYMPTOMS OF BILATERAL SUBTHALAMIC NUCLEUS STIMULATION [J].
LIMOUSIN, P ;
POLLAK, P ;
BENAZZOUZ, A ;
HOFFMANN, D ;
LEBAS, JF ;
BROUSSOLLE, E ;
PERRET, JE ;
BENABID, AL .
LANCET, 1995, 345 (8942) :91-95