Synthesis of a stimulus-responsive processing device and its application to a nucleocytoplasmic shuttle peptide

被引：48

作者：

Shigenaga, Akira

Tsuiji, Daisuke

Nishioka, Naomi

Tsuda, Shugo

Itoh, Kohji

Otaka, Akira ^{[1
]}

机构：

[1] Univ Tokushima, Inst Hlth Biosci, Tokushima 7708505, Japan

[2] Univ Tokushima, Grad Sch Pharmaceut Sci, Tokushima 7708505, Japan

[3] Univ Tokushima, Grad Sch Pharmaceut Sci, Inst Med Resources, Dept Med Biotechnol, Tokushima 7708505, Japan

[4] JST, CREST, Tokyo, Saitama 3320012, Japan

来源：

CHEMBIOCHEM | 2007年 / 8卷 / 16期

关键词：

D O I：

10.1002/cbic.200700442

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stimulus and response. Stimulus-responsive processing (peptide bond cleavage) devices were developed. The processing reaction was triggered by stimulus-induced removal of a PIG, and the processing products were obtained in good purity. A photo-responsive processing device was successfully applied to develop a nucleocytoplasmic shuttle peptide. (F: fluorophore, NES: nuclear export signal. NLS: nuclear localization signal. PG: stimulus-responsive protective group).

引用

页码：1929 / +

页数：4

共 23 条

[21] Click peptides -: Chemical biology-oriented synthesis of Alzheimer's disease-related amyloid β peptide (Aβ) analogues based on the "O-acyl isopeptide method" [J].