Enantioselective oxidations by the diketocamphane monooxygenase isozymes from Pseudomonas putida

被引：21

作者：

Beecher, J

Grogan, G

Roberts, S

Willetts, A

机构：

[1] UNIV EXETER,DEPT BIOL SCI,EXETER EX4 4QG,DEVON,ENGLAND

[2] UNIV LIVERPOOL,DEPT CHEM,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND

来源：

BIOTECHNOLOGY LETTERS | 1996年 / 18卷 / 05期

关键词：

D O I：

10.1007/BF00140205

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

2,5-Diketocamphane 1,2-monooxygenase and 3,6-diketocamphane 1,6-monooxygenase isolated from (+/-)-camphor grown Pseudomonas putida NCIMB 10007 catalysed two different types of Baeyer-Villiger oxidations. The former isozyme biotransformed various bicyclic [3.2.0] ketones and aryl alkyl sulfides with consistently greater regio- and/or enantioselectivity, yielding lactone and sulfoxide products with enantiomeric excesses > 55%.

引用

收藏

页码：571 / 576

页数：6

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