Antifreeze glycoproteins - Structure, conformation, and biological applications

被引：47

作者：

Bouvet, V ^{[1
]}

Ben, RN ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ottawa, ON, Canada

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2003年 / 39卷 / 02期

关键词：

antifreeze glycoproteins; thermal hysteresis; membrane stabilization; vitrification;

D O I：

10.1385/CBB:39:2:133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antifreeze glycoproteins (AFGPs) are a novel class of biologically significant compounds that possess the ability to inhibit the growth of ice both in vitro and in vivo. Any organic compound that possesses the ability to inhibit the growth of ice has many potential medical, industrial, and commercial applications. In an effort to elucidate the molecular mechanism of action, various spectroscopic and physical techniques have been used to investigate the solution conformations of these glycoproteins. This review examines the characterization of AFGPs and potential biological applications relating to stabilization of lipid membranes and vitrification adjuvants.

引用

页码：133 / 144

页数：12

共 68 条

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Ananthanarayanan VS, 1989, LIFE CHEM REPORTS, V7, P1

[2] SYNTHESIS OF A CLOSE ANALOG OF THE REPEATING UNIT OF THE ANTIFREEZE GLYCOPROTEINS OF POLAR FISH [J].