Limiting the proliferation of polyploid cells

被引：148

作者：

Ganem, Neil J.

Pellman, David

机构：

[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Childrens Hosp, Dept Pediat Hematol Oncol, Boston, MA 02115 USA

来源：

CELL | 2007年 / 131卷 / 03期

关键词：

D O I：

10.1016/j.cell.2007.10.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many errors in cell division lead to failure of cytokinesis and the generation of tetraploid cells. Given that tetraploidy can have deleterious consequences, such as genetic instability, we discuss the mechanisms that may have evolved to directly or indirectly prevent the proliferation of these cells.

引用

收藏

页码：437 / 440

页数：4

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